In most cases, Isolate is automatically handled and assumes that you don’t want Invaders to consider the Isolated land to be adjacent to anything. However, it can be advantageous to decide, so certain Powers will ask you to decide what lands are considered adjacent to the Isolated land.
For Fear, Invader, and Event effects, if you want to control the adjacency decisions, enable the Prompt for Isolated Land Adjacency toggle in the in-game menu. In multiplayer, the Spirit Leader controls the toggle.